Peering into the secrets of phages to see how they kill bacterial superbugs
Antimicrobial resistance (AMR) infections affects all aspects of society and is driven by many interconnected factors including antibiotic overuse, and the rapidly adaptive nature of bacteria to evolve into drug-resistant forms. At-risk groups for AMR infections are many, and include COVID-19 patients on respirators, mothers and children during childbirth, surgery patients, people with cancer and chronic disease and the elderly.
A research collaboration involving Monash University has made an exciting discovery that may eventually lead to targeted treatments to combat drug-resistant bacterial infections, one of the greatest threats to global health.
The study outlines the use of high-resolution imaging to uncover how viruses known as phages can attack and kill Salmonella typhi, the causative agent of typhoid, providing scientists with a new understanding of how they can be used in the ongoing fight against AMR.
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